Research Interests
LATEST NEWS
Welcome to Emile
January 2024
We wish to welcome Emile Al Ghoul who just joined our team as a post-doc!
DECLICS session in Carcassonne
December 2023
Members of our team went to Carcassone as part of the DECLICS sessions which favor discussions between researchers and High School students to interest them in the construction of knowledge.
Congrats to Ikrame for the ARC passerelle!
January 2024
Congrats to Ikrame who is the recipient of the "ARC passerelle" funding that aims to facilitate the integration of the most promising non-permanent cancer researchers in France in order for them to prepare for the "concours" to obtain a permanent research position.
Find out more on the ARC website or on an interview she gave to France Bleu.
Welcome to our new PhD students
November 2023
Welcome to Romane Carette, Léa Pradel and Jessica Frison!
Congrats to Florian! You're now a doctor!
December 2023
Congrats to Florian Saur who passed his PhD viva with great sucess!
Our article highlighted on the CNRS webpage
October 2023
Please find out more about our recent discoveries regarding the mechanism of DSB repair
Congrats Sarah for your PhD defense
December 2023
Congrats to Sarah Collins who passed her PhD viva with great sucess!
Our research published in Nature
November 2023
The appearance of chromosomal translocations is a frequent cause of cancer. But how do they occur? In a study published in the journal Nature, we show that when DSb arise, a new chromatin compartment is formed. This chromatin compartment (known as "D") promotes the activation of signalling genes that alert the cell of the presence of such damage. Yet, this signalling has also detrimental effect as it can also give rise in some rare cases to chromosomal trabslocations.
RECENT ARTICLES
October 2023
This article Nature shows that a novel chromatin compartment forms in response to DSB induction.
April 2022
This article in Nat Comm shows that upon excessive RNA:DNA hybrid accumulation, DNA synthesis is enhanced at DSBs, in a manner that depends on BLM and POLD3
June 2021
This review article in DNA repair discusses about the way DSBs occurring in actively transcribed loci are handled