Gaëlle Legube did her undergraduate studies in Life Sciences at the University of Poitiers. She then performed her PhD in Molecular Biology and Genetics at the University Paul Sabatier (Toulouse, France) in the team of Didier Trouche (1999-2003) on histone modifications in human cells. She joined Asifa Akhtar's lab at the EMBL (Germany) for her first post-doc fellowship on dosage compensation in Drosophila (2003-2006). In 2006 she came back to France as a researcher (staff scientist) in the team of Didier Trouche, and and started her own lab at the CBI, in Toulouse in 2011. Gaëlle was awarded the bronze medal of the CNRS in 2012. In 2019, she obtained the Coup d'Elan from the Fondation Bettencourt, as well as the Del Duca prize in cancerology from the French Science Academy. This year (2020), she awarded the CNRS Silver medal.

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Gaëlle developed the DIvA system that relies on the AsiSI restriction enzyme to induce DSBs in human cells (Iacovoni et al., 2010).