The team

GAELLE LEGUBE

Principal Investigator (CNRS)

(HDR)

Team leader since in 2011. She set up the DIvA cell system that relies on the AsiSI restriction enzyme to generate DSBs at annotated positions across the human genome.

THOMAS CLOUAIRE

Researcher (INSERM)

(HDR)

Joined the team in 2013.

Research Interests:

Chromatin and genome-wide methods.

EMMANUELLE GUILLOU

Maîtresse de conférences at the University Paul Sabatier (Toulouse).

Joined the team in 2021.

Manu works on the mechanisms leading to 53BP1 foci assembly.

EDITH GOURBEYRE

"Ingénieure d'étude"

Joined the team in 2022

Edith mainly works with Ikrame, and contributes to differents projects in the lab,

EMILE ALGHOUL

Post-doc

Joined the team in 2024

Emile is investigating the function of physiological DSBs

RIMA KOCHMAN

Post-doc

Joined the team in 2025

Rima is investigating DSB clustering and tethering to the nuclear enveloppe

LEA PRADEL

PhD Student

Joined the team in 2023 for a PhD.

Lea works on the consequences and regulation of DSB-induced RNA:DNA hybrids, supervised by Aline

JESSICA FRISON

PhD Student

Joined the team in 2023 for a PhD

Jessica is a Cohesinet fellow

supervised by Emmanuelle and Thomas Mangeat from the LITC facility at the CBI

Jessica works on the mechanisms leading to 53BP1 foci assembly.

NADINE PUGET

Researcher (INSERM)

(HDR)

Joined the team in 2015.

Research Interests:

Characterization of new players in DSB repair and translocation assays.

ALINE MARNEF

Researcher (CNRS)

(HDR)

Joined the team in 2015.

Research Interests:

R-loops

Nucleolus

Organizer of the conference chromatin meets south 2025

ANNE-LAURE FINOUX

Research Engineer (CNRS)

Joined the team in 2016.

Responsible for the GenSCAN Platform

NATHALIE FIRMIN

Technical support

Joined the team in 2018.

Nathalie helps organizing the lab.

IKRAME LAZAR

Maîtresse de conférence at the University Paul Sabatier (Toulouse).

Joined the team in 2021 for a post-doc. She is now maîtresse de conférence since September 2025. Ikrame investigates the function and consequences of of DSB-induced R-loops