Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.
This review article in Nature Cell Biology discusses about the formation and function of R-loops that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.
This paper shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.