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chromatin landscape at DSB Gaelle legube

Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin. Oour research is performed at the MCD unit within the CBI in Toulouse, France.

LATEST NEWS

Congrats to Gaëlle for the "prix Allianz" from the french accademy

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November 2024

This prize was awarded for her major research achievments, which has led or may lead to clinical applications likely to increase life expectancy through preventive or curative action.

Congrats to Emile

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November 2024

Congrats to Emile for his Medal that rewarded the "major French advances in biology" from the Mergier Bourdeix Fondation .

Congrats to Emile

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June 2024

Congrats to Emile for his Medal that rewarded the "major French advances in biology"

Welcome to Emile

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January 2024

We wish to welcome Emile Al Ghoul who just joined our team as a post-doc!

RECENT ARTICLES

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October 2023

This article Nature shows that a novel chromatin compartment forms in response to DSB induction.

BLM POLD3 SETX and R-loops DSB.JPG

April 2022

This article in Nat Comm shows that upon excessive RNA:DNA hybrid accumulation, DNA synthesis is enhanced at DSBs, in a manner that depends on BLM and POLD3

DSB in active loci.JPG

June 2021

This review article in DNA repair discusses about the way DSBs occurring in actively transcribed loci are handled

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