Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.
Summer Night out
Night out with the whole team!
This article in Nat Comm shows that upon excessive RNA:DNA hybrid accumulation, DNA synthesis is enhanced at DSBs, in a manner that depends on BLM and POLD3
This review article in Nature Cell Biology discusses about the formation and function of R-loops that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.