Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.

LATEST NEWS

Loop extrusion story out in Nature!

Coline's paper is now out in Nature! It shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.

For more, also check on the CNRS website.

cohesin-mediated loop extrusion.jpg

February 2021

"Femmes Inspirantes, Femmes remarquables"

On the occasion of the International Day for Women's Rights on March 8 and the establishment of a Month dedicated to gender equality, the City of Toulouse is working to strengthen the visibility of women in space public and promote substantive equality between women and men.

Gaëlle is one of the chosen women that has an inspiring life path and professional orientation that testify to great progress in terms of social roles traditionally attributed to women and men.

Gaëlle Legube - femme inspirante toulous

March 2021

Welcome back to Manu!

Manu who did her second post-doc in the team joined the lab in January 2021

Emmanuelle Guillou

January 2021

RECENT ARTICLES

JANUS FACED.PNG

April 2021

This review article in Nature Cell Biology  discusses about the formation and function of  R-loops  that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.

loop extrusion.JPG

February 2021

This paper shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.

XRCC4 RAD51 BLESS.JPG

August 2020

Analyzing Homologous Recombination at a Genome-Wide Level

This chapter is part of the Methods in Molecular Biology book and highlights how to analyze HR at the genome-wide level.