Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.

LATEST NEWS

First night out with the team since ages!

Finally a pause in the covid19 pandemic in France!

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July 2021

ERC advanced awarded!

Woaw, we got it!

ERC advanced Gaëlle Legube.PNG

April 2021

New review on the Repair of DSBs at transcribed loci

This review in DNA repair focusses on how active genes are repaired

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June 2021

New Review on DSB-induced R-loops

This review in NCB describes the role of DSB-induced R-loops

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April 2021

RECENT ARTICLES

DSB in active loci.JPG

June 2021

This review article in DNA repair discusses about the way DSBs occurring in actively transcribed loci are handled

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April 2021

This review article in Nature Cell Biology  discusses about the formation and function of  R-loops  that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.

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February 2021

This paper shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.