chromatin landscape at DSB

Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.

LATEST NEWS

Sarah, Aude and Ikrame's paper is out!

A POLD3/BLM dependent repair pathway handles DSBs upon the presence of excessive R-loops

BLM POLD3 SETX and R-loops DSB.JPG

April 2022

Emma Lesage PhD Defense

Congrats to Emma Lesage who succesfully obtained her PhD this 13th December!

IMG_20211213_194742-small.jpg

December 2021

Unit retreat

We had a nice time at our unit (MCD) retreat!

IMG_20220322_121813.jpg

March 2022

Welcome Laure and Emmanuelle

Welcome to Laure Guitton-Sert (post-doc) and Emmanuelle Maciel (PhD student) who recently joined the team!

IMG_20211216_162539-small.jpg

December 2021

RECENT ARTICLES

DSB in active loci.JPG

June 2021

This review article in DNA repair discusses about the way DSBs occurring in actively transcribed loci are handled

JANUS FACED.PNG

April 2021

This review article in Nature Cell Biology  discusses about the formation and function of  R-loops  that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.

loop extrusion.JPG

February 2021

This paper shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.