Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin. Oour research is performed at the MCD unit within the CBI in Toulouse, France.
Welcome to Emile
We wish to welcome Emile Al Ghoul who just joined our team as a post-doc!
DECLICS session in Carcassonne
Members of our team went to Carcassone as part of the DECLICS sessions which favor discussions between researchers and High School students to interest them in the construction of knowledge.
Congrats to Ikrame for the ARC passerelle!
Congrats to Ikrame who is the recipient of the "ARC passerelle" funding that aims to facilitate the integration of the most promising non-permanent cancer researchers in France in order for them to prepare for the "concours" to obtain a permanent research position.
Welcome to our new PhD students
Welcome to Romane Carette, Léa Pradel and Jessica Frison!
Congrats to Florian! You're now a doctor!
Congrats to Florian Saur who passed his PhD viva with great sucess!
Congrats Sarah for your PhD defense
Congrats to Sarah Collins who passed her PhD viva with great sucess!
Our research published in Nature
The appearance of chromosomal translocations is a frequent cause of cancer. But how do they occur? In a study published in the journal Nature, we show that when DSb arise, a new chromatin compartment is formed. This chromatin compartment (known as "D") promotes the activation of signalling genes that alert the cell of the presence of such damage. Yet, this signalling has also detrimental effect as it can also give rise in some rare cases to chromosomal trabslocations.
This article in Nat Comm shows that upon excessive RNA:DNA hybrid accumulation, DNA synthesis is enhanced at DSBs, in a manner that depends on BLM and POLD3