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chromatin landscape at DSB

Research Interests

Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.

LATEST NEWS

Fancy dress at our MCD unit retreat

We all went to St Lary Soulan for our MCD unit retreat. Dress code for our team for the evening pary: "Where is Wally?"

Legube_team_whereiswally.jpg

April 2023

Christmas dinner

We finally had our Christmas dinner in late January!

Legube_team_2023.jpg

January 2023

Welcome to our Master students

Welcome to Léa Pradel and Romane Carrette who joined the team in January for their Matser 2 internship

Romane_carrette_Lea_pradel.jpg

January 2023

Congrats Ikrame !

Congrats to Ikrame for the second young researcher prize from the Fonroga foundation

Ikrame Lazar_edited.jpg

November 2022

RECENT ARTICLES

BLM POLD3 SETX and R-loops DSB.JPG

April 2022

This article in Nat Comm shows that upon excessive RNA:DNA hybrid accumulation, DNA synthesis is enhanced at DSBs, in a manner that depends on BLM and POLD3

DSB in active loci.JPG

June 2021

This review article in DNA repair discusses about the way DSBs occurring in actively transcribed loci are handled

JANUS FACED.PNG

April 2021

This review article in Nature Cell Biology  discusses about the formation and function of  R-loops  that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.

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