Our research aim is to understand the molecular mechanisms responsible for the maintenance of genome integrity. Our lab particularly focuses on DNA double strand break repair in the context of chromatin.
Support for breast cancer research by ARC
Ikrame and Aline have performed the "triathalon des roses" in support of breast cancer research of the ARC fundation. They have raised more than 700 euros for this cause.
This review article in Nature Cell Biology discusses about the formation and function of R-loops that accumulate in cis to DSBs, especially those induced in transcriptionally active loci.
This paper shows that TADs are needed for the establishment of yH2AX domains in a cohesin-mediated loop extrusion manner. A news and views by Leonid Minry nicely summarizes this article.